Monday, March 17, 2008

Sometimes errors occur when cells divide into two daughter cells.. These errors are called genetic mutations.. That means that some bases are lost, substituted, inserted or broken.. Literally thousands of human diseases associated with genetic mutations have been catalogued in recent years , with more being described continually.. A recent reference book of medical genetics listed some 4500 different genetic diseases.. Some of the inherited syndromes characterized clinically in the days before molecular genetic analysis are now being shown to be heterogeneous ; that is, associated with many different mutations.. This review will only scratch the surface of the many recent discoveries.. Still , the examples cited will illustrate a compelling general principle which extends throughout this expanding field.. Mutations are defined as random changes in cellular DNA.. They change the genetic code for amino acid sequence in proteins , thus introducing biochemical errors of varying degrees of severity.. Mutations have been classified as deletions , insertions , and missense or nonsense.. If the mutations affect germ cells , they will be passed to all the cells of the offspring , and affect future generations.. Such mutations are called Germline Mutations , and are the cause of inherited diseases.. Mutations also occur in other populations of body cells and will accumulate throughout a lifetime without being passed to the offspring.. These are called Somatic Mutations , and are important in the genesis of cancers and other degenerative disease processes.. Thus, the question remains : What do we actually see in the world around us when we use scientific tools of measurement and observation? To summarize, recent research has revealed literally tens of thousands of different mutations affecting the human genome , with a likelihood of many more yet to be characterized.. These have been associated with thousands of diseases affecting every organ and tissue type in the body.. The medical descriptions of many forms of inherited disease have a common theme : 80-90% of cases have affected individuals in the family tree , but the remaining cases are sporadic - the result of ever increasing numbers of new mutations.. In all this research, not one mutation that increased the efficiency of a genetically coded human protein has been found.. A slight but definite ongoing mutation rate , accompanied by a zero rate of positive genetic change , will eventually turn the human genetic code to gibberish.. The problem is like a large book , written with perfect grammar in the beginning , but with random letter substitutions introduced at an ongoing rate.. The book will still be readable for some time , but it will eventually lose all sense.. Just as the universe is projected to reach a state of maximum entropy , so also the human race is condemned to a degenerative death , not just as individuals , but as a whole..
This literally means the end of the world for humans if we don't find a way to prevent Genetic mutations.. So let us all pray hard for our future , for our future descendants as well.. Enjoy whatever you're doing now cause you'll never know when is the end coming..
Signing off here...

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